Basic Information
VIS ID
TVIS10014372
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
55618647/57951415 (Hg38)
End
55618647/57951415 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA18B
Nearest miRNA
hsa-mir-1-2/Upstream/2472117; hsa-mir-122/Downstream/499659;
Nearest TSS
ENST00000575820/Upstream/148314; ENST00000617539/Downstream/12104;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/147384, chr18-CpG: 168/Downstream/92181
Nearby gene
ATP8B1(-148320) ; NEDD4L(+92963) ;
Nearest cancer related gene
NEDD4L(TSG, +92963) ;
Upstream sequence
aagtcatgatgaagagtgcatggtccgtgacaggcaaaccAAAACTAAAAACAAATGAGCTACGGGAACTGAGTGCTTAATGGCATCAGATCTTTTTACT
Downstream sequence
AAATATGTTTATTTCCACAACAGAGAAGTTGCTTCCCAGTGGCACACCCAGATGCTTCATGGAAGGGCACACCTCTGGGGTGGTGCTGGGTTCAGACTGG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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