Basic Information
VIS ID
TVIS10014379
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr2
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
150673436/149816922 (Hg38)
End
150673436/149816922 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LINC01931 ; LOC101929231
Nearest miRNA
hsa-mir-128-1/Upstream/486549; hsa-mir-10b/Downstream/1551412;
Nearest TSS
ENST00000437798/Upstream/229106; ENST00000437118/Downstream/40763;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/485944, chr2-CpG: 118/Downstream/668306
Nearby gene
MMADHC(-229106) ; RND3(+651271) ;
Upstream sequence
TATAAAATTGGTAGTTGTTTGTAGTGCTGGCAGAGTCTCAAATGATATATGATATTTGTTGTGTTACAGTCATTTCCAACCAAAGGATTCATTTTTGCAG
Downstream sequence
CAGACGAAAGATGGACAGCATGCAAATGCTTGGATTAGACACAGTCCAATGCTTTGAAATTCCATGCATTGGTGTCTGTTATATGTGTTGTTTTTTGACA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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