VISDB Viral Integration Site DataBase

VIS ID

TVIS10014380

Fusion event

HBV-SP3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

780

Orient

-

Integrated sequence

ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC| |TTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTAT

Chromosome

chr2

Cytoband

q31.1

Reference genome

Start

End

174824061/173959333 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-27a-3p ; hsa-mir-223-3p ; hsa-mir-124-3p ; hsa-mir-484 ; hsa-mir-1260b ; hsa-mir-218-5p

Nearest miRNA

hsa-mir-128-1/Upstream/5376315; hsa-mir-10b/Downstream/1208300;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/603693, chr2-CpG: 54/Downstream/4269

Upstream sequence

AAGCACAATCAAATTTCTTTGTAAAAGAAATTTCATCAGCAATATACCACTAAAAGAGATAAAGTACACTAAATACCAAATGGGAGAGGAATAAATTAGA

Downstream sequence

AAATCATCTGAGACCAAAAAAAAAAAAAAGTTTGAAAAATGTTTGATGTTAGACTACTGGAAACACTACAGAAACAAAAGAATAAAAGGAGATTTAAAAA