VISDB Viral Integration Site DataBase

VIS ID

TVIS10014382

Fusion event

HBV-TFPI integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2182

Orient

+

Integrated sequence

TGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGG| |GCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCG

Chromosome

chr2

Cytoband

q32.1

Reference genome

Start

End

188334413/187469686 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-335-5p ; hsa-mir-155-5p ; hsa-mir-132-3p ; hsa-mir-7-5p ; hsa-mir-98-5p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-1273e ; hsa-mir-6807-5p ; hsa-mir-185-3p ; hsa-mir-4283 ; hsa-mir-4489 ; hsa-mir-5001-5p ; hsa-mir-762 ; hsa-mir-4498 ; hsa-mir-4492 ; hsa-mir-4430 ; hsa-mir-3652 ; hsa-mir-6077 ; hsa-mir-1233-3p ; hsa-mir-4699-5p ; hsa-mir-1225-3p ; hsa-mir-653-5p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-655-5p ; hsa-mir-1273f ; hsa-mir-4708-5p ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-432-5p ; hsa-mir-6736-5p ; hsa-mir-4701-3p ; hsa-mir-1262 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-4648 ; hsa-mir-542-3p ; hsa-mir-3649 ; hsa-mir-661 ; hsa-mir-4745-5p ; hsa-mir-4481 ; hsa-mir-4725-5p ; hsa-mir-6776-5p ; hsa-mir-5699-3p ; hsa-mir-766-3p ; hsa-mir-4421 ; hsa-mir-6742-3p ; hsa-mir-339-5p ; hsa-mir-6849-3p ; hsa-mir-759 ; hsa-mir-10b-5p ; hsa-mir-10a-5p ; hsa-mir-4797-5p ; hsa-mir-27a-3p ; hsa-mir-494-3p

Nearest miRNA

hsa-mir-10b/Upstream/3090642; hsa-mir-1244-1/Downstream/827806;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/620344, chr2-CpG: 106/Downstream/822003

Upstream sequence

tacatttttgtgtgtgtgacaagggtagctaaaatctacttatataacagaaatccctaacacaatactgttttactaactgtcatcttcatgttgtaca

Downstream sequence

ttagatctctaggcttatttatcctacatgcctgtattttgtatcctttgacATGATGATATGCCATCATAAATCAAAGTTGAATGGTGAGAATGTGTGC