Basic Information
VIS ID
TVIS10014392
Fusion event
HBV-ABHD16B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2511
Orient
-
Integrated sequence
GCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACC| |TGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTT
Host Sequence
Chromosome
chr20
Cytoband
q13.33
Reference genome
GRCh37/hg19
Start
62492502/63861149 (Hg38)
End
62492502/63861149 (Hg38)
Orient
+
Location type
upstream
Target gene
ABHD16B
Nearest miRNA
hsa-mir-1-1/Upstream/574283; hsa-mir-1914/Downstream/58300;
Nearest TSS
ENST00000382410/Upstream/29905; ENST00000369916/Downstream/349;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/28411, chr20-CpG: 158/Downstream/347
Upstream sequence
TAAGGAAGAGGGAggcggggtgcagggactcacacctgtaatcccaacactgtgggaggTGGAggcggggtgcagggactcacacctgtaatcccaacac
Downstream sequence
tgtgggaggtggaggcgggaggatcgcttgagcccaggggttcaagaccagcctaggcagcatagtgagaccccatctcaatttaataaataaataaGGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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