Basic Information
VIS ID
TVIS10014394
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|
Start
2080
Orient
+
Integrated sequence
GTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTC| |TTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATAT
Host Sequence
Chromosome
chr21
Cytoband
q21.1
Reference genome
End
18014025/16641706 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/51381; hsa-mir-155/Downstream/2044384;
Nearby gene
MIR99AHG(-31931) ; LINC01549(+797183) ;
Nearest cancer related gene
MIR99AHG(OG, -31931) ;
Upstream sequence
ttcatgctcctatgagaatctaatgccactgctgatctgacaggaggcagagctcaggcagtaatgctcactagttccgttgctcgcctcctgctgtgca
Downstream sequence
gcccagttcctaacaggacacagaccagtactggttcgcaacccagggtttgggggcccctgTCTTAGTTCCTTTGCCTTCCTTCcagatggatgcctgg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate