Basic Information
VIS ID
TVIS10014396
Fusion event
HBV-chr21 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1807
Orient
-
Integrated sequence
CTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCA| |CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA
Host Sequence
Chromosome
chr21
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
25774295/24401981 (Hg38)
End
25774295/24401981 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7c/Upstream/1322589; hsa-mir-155/Downstream/1171999;
Nearest TSS
ENST00000624081/Upstream/80604; ENST00000423581/Downstream/26759;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/3403736, chr21-CpG: 28/Downstream/959813
Nearby gene
D21S2088E(-1017139) ; LINC01692(+438569) ;
Upstream sequence
tgtgctgggcacctgtagtcacagctactcgggaggctgaggcaggagaatggcatgaacccgggaggcggagcttgcagtgagccaagatcgcgcctct
Downstream sequence
gcactccagcctgggcgacagagcgagactctgtctcaaaaaaaaaaaaaaagaaaaaGTCAATTATTTTTTGCTATAACAGGGATAAatacatcaaaca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate