Basic Information
VIS ID
TVIS10014397
Fusion event
HBV-LARGE1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1989
Orient
+
Integrated sequence
GTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGAT| |CTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGG
Host Sequence
Chromosome
chr22
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
34153291/33757304 (Hg38)
End
34153291/33757304 (Hg38)
Orient
+
Location type
Intronic
Target gene
LARGE1
miRNAs that regulate target gene
hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1286/Upstream/320635; hsa-let-7a-3/Downstream/1578336;
Nearest TSS
ENST00000624155/Upstream/100088; ENST00000610170/Downstream/104320;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/106693, chr22-CpG: 275/Downstream/162549
Upstream sequence
ttcttacagggagacaatgcctgcctccccataacatttatgcattgatcctgcttccatgctcaggagcaaatcacagtaagcctaagccgactccctc
Downstream sequence
ttAGTGTCATAATTCCCCTTAATCGGGGAAGATTCTGGTCATTTTCAGTTCACTTACATCAGACGTTAGAATCAGAAGCTTGTAGGTAGAATGTCGGCAC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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