Basic Information
VIS ID
TVIS10014402
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
46156781/46115289 (Hg38)
End
46156781/46115289 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12127/Upstream/1253308; hsa-let-7g/Downstream/1734266;
Nearest TSS
ENST00000440867/Upstream/87547; ENST00000484025/Downstream/48315;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/119308, chr3-CpG: 26/Downstream/349382
Nearby gene
XCR1(-87802) ; CCR1(+86419) ;
Upstream sequence
GGAGAAGTATTCAACAAAACATCCAGTACAAGAAGTGCCTGAAGAATGAAAACTGTTCTATAATGAGAATGAATAGGAACAGATGTCAGCAATGTCGCTT
Downstream sequence
attcaggcaagcatttgtggttacaaccaaatcatctttttctagtaatatggcgtcatattttagaaactgagaatccgttaactatctcccggctttt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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