Basic Information
VIS ID
TVIS10014403
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr4
Cytoband
q28.1
Reference genome
GRCh37/hg19
Start
127747717/126826562 (Hg38)
End
127747717/126826562 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/1319255; hsa-mir-1305/Downstream/16516898;
Nearest TSS
ENST00000502981/Upstream/755854; ENST00000504491/Downstream/251200;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1508787, chr4-CpG: 86/Downstream/796314
Nearby gene
MIR2054(-1319255) ; INTU(+806370) ;
Upstream sequence
atgataggccaatgacatccacttggcagggctatcctggggTTCGCTGGCACAGGAGATGTGGCATGAGCTCTCACCAGGCTCATCCGAAAAGCTTTTG
Downstream sequence
tatgtgtatgtatatatatatatatatatatctgtgtatatatatatatatatatatatatatatatatatatatatctcctattagttctgtccctcta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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