Basic Information
VIS ID
TVIS10014406
Fusion event
HBV-LOC339975 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1656
Orient
-
Integrated sequence
GTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACA| |TAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATT
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
188314070/187392916 (Hg38)
End
188314070/187392916 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LOC339975
Nearest miRNA
hsa-mir-12113/Upstream/2454476;
Nearest TSS
ENST00000502981/Upstream/22268; ENST00000503677/Downstream/20648;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/29668, chr4-CpG: 27/Downstream/112240
Upstream sequence
taaccttgatcacttggttaagattgtctgccaaatttctccactgtaatttttttttcctttttcttagtcttttctttggaagccagtcactaagtct
Downstream sequence
tttacaaaactgaaaacaggatttagaaaaaccaaaatgggaggtacaatattccagagctagtaacaggaagctgtttgcaggactaagctgacaggag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate