Basic Information
VIS ID
TVIS10014412
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2201
Orient
-
Integrated sequence
CTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACT| |CTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGA
Host Sequence
Chromosome
chr5
Cytoband
q34
Reference genome
GRCh37/hg19
Start
165769458/166342453 (Hg38)
End
165769458/166342453 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10397/Upstream/5857003; hsa-mir-103a-1/Downstream/1823392;
Nearest TSS
ENST00000502646/Upstream/213955; ENST00000517586/Downstream/583917;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/2836513, chr5-CpG: 17/Downstream/636026
Nearby gene
TENM2(+942385) ;
Upstream sequence
TGTGCCCACGTGACGATGGAGACAGGAGGACCAGGGCTCTGCCTGCCCCCTTTTCTGAGCCCCTACTGCATTCAGCTCTGGGGCCTGGGCCCTCGACGGC
Downstream sequence
aggtcctgttagacattctgctgttatccaaatgagacttccggcagatgtctggagagttgaaatccccatcactacTCtgtcttttctctgcactgat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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