Basic Information
VIS ID
TVIS10014413
Fusion event
HBV-RPSAP40 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2310
Orient
+
Integrated sequence
TCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAAT| |GCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAAT
Host Sequence
Chromosome
chr6
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
148969226/148648090 (Hg38)
End
148969226/148648090 (Hg38)
Orient
-
Location type
Intronic
Target gene
RPSAP40
Nearest miRNA
hsa-mir-10398/Upstream/7964207; hsa-mir-1202/Downstream/2454585;
Nearest TSS
ENST00000381078/Upstream/120825; ENST00000473631/Downstream/99238;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/87785, chr6-CpG: 157/Downstream/98726
Nearby gene
SASH1(-96042) ; UST(+99045) ;
Upstream sequence
AAATATTACGCTTTCAGAAAAATCTTTTGAATCTCTGCCTATAAAACCATTACTATATCATATATAAAACTCATACTCTTCCTTCTCTGTGTATAATATT
Downstream sequence
TGCCCTTGTTGTTGCAGGGGATGGCAATGTCCACAGCGCAGACGAGAATCTGTGTGACCCAAAGCAATGGTAGGCAGGTTAGCATAAGACACCTCTGTGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate