Basic Information
VIS ID
TVIS10014417
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1830
Orient
+
Integrated sequence
ACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCAC| |CTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTG
Host Sequence
Chromosome
chr7
Cytoband
q33
Reference genome
GRCh37/hg19
Start
136201734/136516986 (Hg38)
End
136201734/136516986 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/1309908; hsa-mir-10399/Downstream/386181;
Nearest TSS
ENST00000635602/Upstream/89591; ENST00000471195/Downstream/351683;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/539462, chr7-CpG: 154/Downstream/352121
Nearby gene
LUZP6(-539530) ; CHRM2(+351665) ;
Upstream sequence
CCTCTCCCCTTTCGTCACCCCCACACACAGGACATTTGCGTACTGGGAGAACCTTTATTAGATGATTCTGATAAACCTTCTCCTTATCCCCACGTGAAAC
Downstream sequence
ataactgagtgccactcttagagattctgatttTTTTTCCAGCCAGGTTTGAGGGTAGAAAATTTAGGTACAGGATTAAAAATTTTACAGTCAATTCTAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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