Basic Information
VIS ID
TVIS10014419
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr7
Cytoband
q35
Reference genome
GRCh37/hg19
Start
145601876/145904783 (Hg38)
End
145601876/145904783 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10399/Upstream/2521983; hsa-mir-153-2/Downstream/1473234;
Nearest TSS
ENST00000635602/Upstream/223414; ENST00000637105/Downstream/211219;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1068623, chr7-CpG: 70/Downstream/211399
Nearby gene
TPK1(-1068730) ; CNTNAP2(+211577) ;
Nearest cancer related gene
CNTNAP2(TSG, +211577) ;
Upstream sequence
tccagccaaactaagcttcataagtgaaggagaaataaaatactttatagacaagcaaatgctgagagattttgtcaccaccaggcctgccctaaaagag
Downstream sequence
tatatgcatgtttagctttgaaagatgttgagaaacaagttttgttttcaagcaattgtattaatcttaataccagttgttctacatccttgccaatgct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate