Basic Information
VIS ID
TVIS10014423
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1842
Orient
+
Integrated sequence
TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC| |ATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGG
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90084692/90455378 (Hg38)
End
90084692/90455378 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/14540109; hsa-mir-10399/Downstream/1748637;
Nearest TSS
ENST00000635602/Upstream/49797; ENST00000478752/Downstream/7862;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/108665, chr7-CpG: 141/Downstream/140390
Nearby gene
CLDN12(-39424) ; CDK14(+254020) ;
Nearest cancer related gene
CDK14(OG, +254020) ;
Upstream sequence
TTTGATAACACTAATCTCGAGTGTAGTTAAATATTATACCAACCAGTATCAATTTTGTGCACAGAGGTTTCTATTTTATCTCATACCAATATAGAAGAAT
Downstream sequence
gtgcttcaccgtccttggttattgttactcttgacacacctctgtatttagtcccttcattgaattctcttcaattaaccTTCCTGCTGGGCTGCTTACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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