Basic Information
VIS ID
TVIS10014427
Fusion event
HBV-LOC644661 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1919
Orient
+
Integrated sequence
AACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTA| |TAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGG
Host Sequence
Chromosome
chr9
Cytoband
q31.2
Reference genome
GRCh37/hg19
Start
109936448/107174167 (Hg38)
End
109936448/107174167 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC644661
Nearest miRNA
hsa-let-7a-1/Upstream/573145; hsa-mir-12126/Downstream/1872062;
Nearest TSS
ENST00000422679/Upstream/52462; ENST00000442587/Downstream/108970;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/313245, chr9-CpG: 125/Downstream/108664
Nearby gene
MIR548Q(-87732) ; RAD23B(+109069) ;
Upstream sequence
gaaggaaattgaacaatttcttgaaatatataataatggaaatacaacataccaaaacctatgggatacagcaaaagtagtactaagaggcaagtttata
Downstream sequence
GTTTGCAATGAACTTGCACTTTCAATTTGAAACAGAGATGGATGTGCATCAGCAAAATCAAGGAAGTGATCACTCCTCTCTACAGGAATAGGATATCACC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate