Basic Information
VIS ID
TVIS10014429
Fusion event
HBV-LOC107987065 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1828
Orient
+
Integrated sequence
AGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTC| |ACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATT
Host Sequence
Chromosome
chr9
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
38327012/38327015 (Hg38)
End
38327012/38327015 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC107987065
Nearest miRNA
hsa-mir-101-2/Upstream/1433484; hsa-let-7a-1/Downstream/2601995;
Nearest TSS
ENST00000422679/Upstream/257804; ENST00000422554/Downstream/33412;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/85432, chr9-CpG: 54/Downstream/65497
Nearby gene
SHB(-257802) ; ALDH1B1(+65649) ;
Upstream sequence
caggcctttggccacagactgaaggctgcactgttggcttccctccttgtgaggttttgggacttggacttatttaccactggcttccttgctccccaac
Downstream sequence
attaaaaaaaatcctgtttggtacttgtgcttatagaatctgaaaattcttacttttcatcaatttgggaatatccttagtcattagagatttcatgcct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate