Basic Information
VIS ID
TVIS10014430
Fusion event
HBV-TEX28P2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1824
Orient
-
Integrated sequence
TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
153431098/154165623 (Hg38)
End
153431098/154165623 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
TEX28P2
Nearest miRNA
hsa-let-7f-2/Upstream/145634; hsa-mir-1184-1/Downstream/284697;
Nearest TSS
ENST00000429181/Upstream/12681; ENST00000595330/Downstream/16973;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/28424, chrX-CpG: 32/Downstream/129765
Nearby gene
OPN1LW(-6591) ; OPN1MW(+16987) ;
Upstream sequence
GCTATTTCATAGCTCTCCAACAAAACTGGGATTGTCACCCTTTCTCGAAAGTTGAGTCCCTCATTTCTGCCAAATTCTGAGGGACTGTGTGGAGCTAAGA
Downstream sequence
AActttctttctttctttctttctttctttctttctttctttctctttttctttctctctctctctctctctctctctctctctctctccctctctctct
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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