Basic Information
VIS ID
TVIS10014434
Fusion event
HBV-LOC107987166 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1905
Orient
+
Integrated sequence
CACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATG| |GACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCT
Host Sequence
Chromosome
chr11
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
116264255/116393538 (Hg38)
End
116264255/116393538 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11G ; FRA11B
Target gene
LOC107987166
Nearest miRNA
hsa-mir-10392/Upstream/2943450; hsa-let-7a-2/Downstream/2250462;
Nearest TSS
ENST00000527297/Upstream/460681; ENST00000439483/Downstream/107092;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/633139, chr11-CpG: 30/Downstream/107004
Nearby gene
LINC00900(-633337) ; BUD13(+354631) ;
Upstream sequence
gcctgggcaacagagcgagactctgtctcaaaaagagcaaaaggaaaaagaaactttgcagatgtgattaaatgaccttgagatatggagattatcctgg
Downstream sequence
tttatccaggtgggctcattctaatcaactgagtccttacagttggagaacctttccaggttatggccagaaaaagatatgaccccagaagcagcatcag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate