Basic Information
VIS ID
TVIS10014436
Fusion event
HBV-LOC105378237 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2943
Orient
-
Integrated sequence
TACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATT| |GGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGG
Host Sequence
Chromosome
chr5
Cytoband
q33.1
Reference genome
GRCh37/hg19
Start
151725653/152346092 (Hg38)
End
151725653/152346092 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105378237
Nearest miRNA
hsa-mir-10397/Upstream/823944; hsa-mir-103a-1/Downstream/2001014;
Nearest TSS
ENST00000502646/Upstream/129018; ENST00000520353/Downstream/59187;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/420829, chr5-CpG: 50/Downstream/1692531
Nearby gene
GLRA1(-421256) ; NMUR2(+45449) ;
Upstream sequence
catgccgaccagccatcagccacatatcctgaagcccagtttccacacagttcactcctccagtgctttctcagacctcagccaccttggcctccctggt
Downstream sequence
TATGGGCAAGCTataatgcttaacatttattgagtgtaaaacttgtttataccatcaatttaagccccttttaatacccctttacatgttattttattga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate