Basic Information
VIS ID
TVIS10014438
Fusion event
HBV-chr9 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|precore/core protein|
Start
1833
Orient
+
Integrated sequence
GGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTC| |TGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAG
Host Sequence
Chromosome
chr9
Cytoband
q22.33
Reference genome
GRCh37/hg19
Start
101030115/98267833 (Hg38)
End
101030115/98267833 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-let-7a-1/Upstream/38616; hsa-mir-12126/Downstream/8333095;
Nearest TSS
ENST00000422679/Upstream/12112; ENST00000610463/Downstream/35501;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/11534, chr9-CpG: 230/Downstream/439464
Nearby gene
TBC1D2(-12112) ; GABBR2(+20249) ;
Upstream sequence
ATGTCTGAGGGATTAATAAGCCAGTTTTGGCTATTATCAGTGCAAATGAGCCACCTAAGTGACAACAGGACAGAAGTGTAGGCTACATTCTCCTCTGCCT
Downstream sequence
gatcattcagggagatctagggtaggggcagtctctaaagttgtcttcagggaacagaaaggagtggggaaaggatttaggatctatggggtcagctagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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