LRP2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014444
Fusion event
HBV-LRP2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
135
Orient
-
Integrated sequence
CAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGG| |ATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCA
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
170046917/169190407 (Hg38)
End
170046917/169190407 (Hg38)
Orient
-
Location type
Intronic
Target gene
LRP2
miRNAs that regulate target gene
hsa-mir-196a-5p ; hsa-mir-146a-5p
Nearest miRNA
hsa-mir-128-1/Upstream/607389; hsa-mir-10b/Downstream/5977226;
Nearest TSS
ENST00000437798/Upstream/7957; ENST00000469980/Downstream/84946;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/299912, chr2-CpG: 119/Downstream/171397
Upstream sequence
TGAATGTCTTTGCATTGTCAGTTCACAAACTACCACCTCTCAGCAATGTCCACTCATCAGAGGATGAATCACCCACAGAGTGTATTTTCCTGATAGCATT
Downstream sequence
TATCTACTTTTTAAATTACTGCTGAGTCCCTGCTCCTTCACCTCCTCCTTCTTCCTCAGGACCACCACAATAAACACACAATCGTACACCACACTGGACT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate