Basic Information
VIS ID
TVIS10014445
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1809
Orient
-
Integrated sequence
TCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACC| |AGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACA
Host Sequence
Chromosome
chr20
Cytoband
q11.23
Reference genome
GRCh37/hg19
Start
36522484/37894082 (Hg38)
End
36522484/37894082 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/2439985; hsa-mir-1-1/Downstream/622481;
Nearest TSS
ENST00000382410/Upstream/46224; ENST00000448944/Downstream/9022;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/199898, chr20-CpG: 101/Downstream/8659
Nearby gene
CTNNBL1(-21964) ; VSTM2L(+9015) ;
Upstream sequence
cttttctctctctctttctttctttctctctctctctttctttctttcctttctttctttcacagagtctttttgtccctcaggctggagtgcagtgcag
Downstream sequence
cagctcaatttcagctcactgcaacctcttccttccaggctcaagtcatcctcccacctccgcctcccaagtagctgggaatacaggcacgtgccaccac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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