Basic Information
VIS ID
TVIS10014446
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1386
Orient
+
Integrated sequence
GCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAG| |GCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTC
Host Sequence
Chromosome
chr7
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
4444735/4405104 (Hg38)
End
4444735/4405104 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7B
Nearest miRNA
hsa-mir-339/Upstream/1877959; hsa-mir-10399/Downstream/383461;
Nearest TSS
ENST00000635602/Upstream/172217; ENST00000460979/Downstream/277205;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/96718, chr7-CpG: 90/Downstream/236704
Nearby gene
SDK1(-136104) ; FOXK1(+277195) ;
Upstream sequence
gcgtgagccactgcacctggccGACagcttcttgagtgtgtgtgttgaaggtaaattttttgagattgagactcctgagtctgaaggaaattttaatttt
Downstream sequence
agagagtatgtgcaggggaaagcccctttataaaaccatcagatctcatgagacttattcactgtcatgagaacagcacagcaaatacccacccccatga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate