Basic Information
VIS ID
TVIS10014449
Fusion event
HBV-IGK integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
2983
Orient
+
Integrated sequence
GATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAA| |CAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCA
Host Sequence
Chromosome
chr2
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
89993645/89954835 (Hg38)
End
89993645/89954835 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2L
Target gene
IGK
Nearest miRNA
hsa-mir-1285-2/Upstream/1142381; hsa-mir-10b/Downstream/6843443;
Nearest TSS
ENST00000437798/Upstream/6865; ENST00000453166/Downstream/5144;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/186734, chr2-CpG: 65/Downstream/283213
Nearby gene
MIR4436A(-881677) ; LSP1P4(+1831064) ;
Upstream sequence
gtaccacatgtgtttaaacaaccagatctcacaaagtactcatcatcatgacagtactaaaccatgagggatgcacccccatgacccccaaacctcccac
Downstream sequence
caggccccatcttcaacattgggaattatatttcaacatgagatttgagtgggataaatatccaaaccatgtcaACATCTATCTTGGCTTTTCTTGGCCG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate