VISDB Viral Integration Site DataBase

VIS ID

TVIS10014450

Fusion event

HBV-PACSIN2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

X protein|Polymerase|

Start

1389

Orient

+

Integrated sequence

GCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCT| |GTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCG

Chromosome

chr22

Cytoband

q13.2

Reference genome

Start

End

43293979/42897973 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-193b-3p ; hsa-mir-7161-5p ; hsa-mir-8087 ; hsa-mir-548u ; hsa-mir-548g-3p ; hsa-mir-548av-3p ; hsa-mir-3691-5p ; hsa-mir-6124 ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-873-5p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-4433b-3p

Nearest miRNA

hsa-mir-1281/Upstream/974676; hsa-let-7a-3/Downstream/2302981;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/27696, chr22-CpG: 113/Downstream/116442

Upstream sequence

GGTGTGTCCACATGGCAACCCTGGGGCCCTGAGAGAAGTCAGCTGGGAATGGAACACAGAACACAGGGAGCAAATGGCAATGAGGGAGGGCAGATGCTGA

Downstream sequence

GAAACTGGGAAGGCTAGGCCTGCATCCTGAAGGGTGTCAGGCTTGGGGACTGGTGGGGCTCAGAAGGCTGGCGGGGGTGGGGACATCCTGGAAGGAAGAA