Basic Information
VIS ID
TVIS10014451
Fusion event
HBV-LOC101927421 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1606
Orient
+
Integrated sequence
CGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGT| |CGCATGGAGACCACCGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCAT
Host Sequence
Chromosome
chr5
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
124405049/125069356 (Hg38)
End
124405049/125069356 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927421
Nearest miRNA
hsa-mir-10397/Upstream/5914640; hsa-mir-103a-1/Downstream/4028332;
Nearest TSS
ENST00000502646/Upstream/32718; ENST00000625219/Downstream/255994;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/417301, chr5-CpG: 30/Downstream/1353999
Nearby gene
ZNF608(-324244) ; GRAMD2B(+1290739) ;
Upstream sequence
gtcctcacggagatcacacctgcaaaggccctggggccgggcgggttctgtccacaggtttgggggaatcaggacgtgggcatctctagagcattatcct
Downstream sequence
tttttccgtaacatcttacatatttatttattttacatattcttttttcacaatttcaacttttattttagattcagggtgtgtgtgtgtagatttgtta
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate