Basic Information
VIS ID
TVIS10014454
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1733
Orient
-
Integrated sequence
CAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACT| |GGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTC
Host Sequence
Chromosome
chr1
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
105657178/105114556 (Hg38)
End
105657178/105114556 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/4833248; hsa-mir-11399/Downstream/2782667;
Nearest TSS
ENST00000473358/Upstream/1364150; ENST00000635102/Downstream/491447;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/1588265, chr1-CpG: 37/Downstream/966215
Nearby gene
LOC100129138(-1037485) ; PRMT6(+1942089) ;
Upstream sequence
cagggaaagaccagcagaaaggaaagagggaaagataaagaaaatcagagagtgagagaggaagagacagagacaaagatggagtcagagagagagagag
Downstream sequence
aaagagagagacagaaagtcaaagagagagaggagacagacaaagagggagtcagaaagagagaaagagagagacaaagaagaagttgaagagaaagaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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