Basic Information
VIS ID
TVIS10014459
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3195
Orient
+
Integrated sequence
CCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG| |
Host Sequence
Chromosome
chr1
Cytoband
q32.1
Reference genome
GRCh37/hg19
Start
198749570/198780441 (Hg38)
End
198749570/198780441 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/2197960; hsa-mir-1182/Downstream/78432;
Nearest TSS
ENST00000473358/Upstream/28086; ENST00000422480/Downstream/46775;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/621207, chr1-CpG: 36/Downstream/1254905
Nearby gene
PTPRC(-22965) ; MIR181A1HG(+27562) ;
Nearest cancer related gene
PTPRC(TSG, -22965) ;
Upstream sequence
CTAGATATTCCCATCTAGTCCTTGTAAATGGAATTTGCAACCTCTTACTCTTCCAGGGTCAAGGCCTCAGTGTTGTCTTTGATCTCATCCCCTTCCTCAC
Downstream sequence
TGCCCATGATTACCAGGACTGGTTGATTGTCTTTTTGCAAAGACTCTGGCAGGTGTCTATTATTTTGATTCCTGCTGCCAAGGCTCTAGTATATGCTCTT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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