Basic Information
VIS ID
TVIS10014465
Fusion event
HBV-chr1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1874
Orient
-
Integrated sequence
CTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTC| |CAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTT
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
69842053/69376370 (Hg38)
End
69842053/69376370 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA1C ; FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/1192760; hsa-mir-11399/Downstream/1691261;
Nearest TSS
ENST00000473358/Upstream/126947; ENST00000448001/Downstream/56885;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/879047, chr1-CpG: 131/Downstream/190914
Nearby gene
DEPDC1(-879254) ; LRRC7(+383805) ;
Upstream sequence
AATTTTGTGGCAAATTAAGGCAATCATTTATTGTAAGGACTAAACTTTCATTAAAGCTACTTCACTATTCAAAACCAAGAGGCTATTTCTCTTACTGCAA
Downstream sequence
TAATAAAGTTTAGAAGTTCTGCTTTTGTTGCCTTTCTCTTCTGATAATTGGaagaaaagagaatggaagggaagataaaaataagactgagtgaaaacag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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