Basic Information
VIS ID
TVIS10014468
Fusion event
HBV-ADGRA1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1241
Orient
+
Integrated sequence
CCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTGGCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGT| |GGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACT
Host Sequence
Chromosome
chr10
Cytoband
q26.3
Reference genome
GRCh37/hg19
Start
134896409/133082905 (Hg38)
End
134896409/133082905 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
ADGRA1
miRNAs that regulate target gene
hsa-mir-124-3p
Nearest miRNA
hsa-mir-107/Upstream/2120237; hsa-mir-202/Downstream/164606;
Nearest TSS
ENST00000439456/Upstream/11976; ENST00000392606/Downstream/3792;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/3007, chr10-CpG: 36/Downstream/281
Nearby gene
LINC01168(-106408) ; ADGRA1(+5000) ;
Upstream sequence
TTGCGCTGGACGCAGAGGCCTGGCCGAGGCACCCTGGACGCAGGCCCTGTGCGGTGAGGCCTTCCAACGTAAAACCCACCCAAGGGGCTCATTCTGCAGG
Downstream sequence
GGGGCCCACAAGCGCCAAAGGGCCTGTTTGCCACACGTGGTGGTCAGTGGGAGCCACGTGAGCTTCCCCGGGGGCCTCCCGCCTCAGAGGAGGGAGACTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate