NMT2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014469
Fusion event
HBV-NMT2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1206
Orient
+
Integrated sequence
ACTTACAAGGCCTTTCTGTGTAAACAATACCTGAACCTTTACCCCGTTGCCCGGCAACGGCCAGGTCTGTGCCAAGTGTTTGCTGACGCAACCCCCACTG| |GCTGGGGCTTGGTCATGGGCCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAG
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
15177632/15135633 (Hg38)
End
15177632/15135633 (Hg38)
Orient
+
Location type
Intronic
Target gene
NMT2
miRNAs that regulate target gene
hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p
Nearest miRNA
hsa-mir-1265/Upstream/698972; hsa-mir-107/Downstream/2709474;
Nearest TSS
ENST00000439456/Upstream/16248; ENST00000433455/Downstream/5720;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/37781, chr10-CpG: 103/Downstream/32192
Upstream sequence
TCCAAGCCCAGTCAAGGCCATGGGCTTGTGTGTTACACATGAAAATAGAAGCAAACCCTCTGTTAAAGGTAACAACAGTTGTCTAGTTTTATTGGGGCTC
Downstream sequence
TGGCAGTTTGGGGAATCTAAATTGAAGCACGCTTTGCTTCAGTTTCCCATCCATCTACAAATGGTCCCCGGCATTACTCCTCTGGGGGAGACGTGCAGTG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate