Basic Information
VIS ID
TVIS10014470
Fusion event
HBV-TMEM72-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1745
Orient
+
Integrated sequence
AAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGG| |GGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATC
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
45443081/44947633 (Hg38)
End
45443081/44947633 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA10G
Target gene
TMEM72-AS1
Nearest miRNA
hsa-mir-1265/Upstream/1949952; hsa-mir-107/Downstream/216381;
Nearest TSS
ENST00000439456/Upstream/10125; ENST00000428466/Downstream/11774;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/82555, chr10-CpG: 66/Downstream/11714
Upstream sequence
CTCTGCAGGCTGGAAGTCACGCTCATCAAGCCCTGTCTGCTGCTGTCAGCTCAGCCTAGAGCCCATACCTTGCTGATGGCATGTTTGCCTGAGAAACAAA
Downstream sequence
CTTCATTCCCTTTTCCTGGAATTCTACCCCATCTCACTCCTCACCAATCTCTCAAAGAGAACTTATCCTTTGGTATGTCCAAATGGGAAAATCTCTTGCT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate