ABCC8 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10014476
Fusion event
HBV-ABCC8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1927
Orient
-
Integrated sequence
CACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAAT| |TTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTT
Host Sequence
Chromosome
chr11
Cytoband
p15.1
Reference genome
GRCh37/hg19
Start
17471943/17450396 (Hg38)
End
17471943/17450396 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA11C ; FRA11I
Target gene
ABCC8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-136-5p
Nearest miRNA
hsa-mir-210/Upstream/1480775; hsa-let-7a-2/Downstream/937391;
Nearest TSS
ENST00000527297/Upstream/6963; ENST00000428619/Downstream/10152;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/60656, chr11-CpG: 93/Downstream/25520
Upstream sequence
tctttctttctttctttctttctttctttctctctctctctttcctttctttctttctttccttcctttcctttcctttctttcctttcctttccttctt
Downstream sequence
tctttccttttttttttTTTcagagtcttgctgtgtcgcccaggctggagtgcggtggtgccatctcggctcactgcaagctcctcctcctgggttcacg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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