Basic Information
VIS ID
TVIS10014478
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
751
Orient
+
Integrated sequence
GCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGT| |GGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACA
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
35616684/35595136 (Hg38)
End
35616684/35595136 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA11E
Nearest miRNA
hsa-mir-1343/Upstream/653216; hsa-let-7a-2/Downstream/414962;
Nearest TSS
ENST00000527297/Upstream/9826; ENST00000532914/Downstream/23283;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/174801, chr11-CpG: 197/Downstream/22945
Nearby gene
PAMR1(-69508) ; FJX1(+23051) ;
Upstream sequence
GAGAAGGAGATGGATGGATTAAATAATACAGAACTCTTCTGCCTGCTTGGCCATTTTCTTCTTGTAATTGAATGCTAAAAAGATGACTTAAAAAAAGAAC
Downstream sequence
AATTTGTCCCACAAAGGTGCATGCATATCTGTTAAACGGTACAAGACACAAAGGGTCATCCCTACAAATGTGATGTGCATTCATTCACTCTAGGCCCCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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