Basic Information
VIS ID
TVIS10014479
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2830
Orient
+
Integrated sequence
CTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCT| |TGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACC
Host Sequence
Chromosome
chr12
Cytoband
q24.21
Reference genome
GRCh37/hg19
Start
116211866/115774061 (Hg38)
End
116211866/115774061 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12E ; FRA12C
Nearest miRNA
hsa-let-7i/Upstream/2482453; hsa-mir-1178/Downstream/374499;
Nearest TSS
ENST00000382841/Upstream/18799; ENST00000549725/Downstream/112076;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/321871, chr12-CpG: 46/Downstream/142921
Nearby gene
TBX3(-1089897) ; MED13L(+184515) ;
Nearest cancer related gene
TBX3(OG, -1089897) ;
Upstream sequence
GATGCCCATTCCTGAACCATCATTCCCAGAATAGAATCCAGACTCATCACTATGGCCCAAGGTCATTCAACCTTGGAATCCAGACTCATGAGAACCGTCT
Downstream sequence
CTTATTCCCTCCTCTACCCTCTAGGATTCCTTCCTCCTTTCCTATTCCtttttttttttttttttttttttaaatattagacacagggtctcactctgtc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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