Basic Information
VIS ID
TVIS10014487
Fusion event
HBV-LINC00333 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2395
Orient
-
Integrated sequence
TATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCA| |GACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTT
Host Sequence
Chromosome
chr13
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
84932782/84358647 (Hg38)
End
84932782/84358647 (Hg38)
Orient
+
Location type
ncRNA_intronic
Target gene
LINC00333
Nearest miRNA
hsa-mir-1297/Upstream/6660531; hsa-mir-1267/Downstream/3260018;
Nearest TSS
ENST00000623511/Upstream/476254; ENST00000446314/Downstream/203717;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/478885, chr13-CpG: 121/Downstream/3312667
Upstream sequence
GAGAGCCCCAGACTTCTGTGTGTGAACATAAAATGCCCACCTTCTTCCACATGACCTTAGAAATAGCAATTATGTTTCTTATTAACTTTGCCAACATTTC
Downstream sequence
CCATGTTATATCATTATGCTGTTTTAAGTACAGCACAGAAAACAGTTCTAAACTATGGTGAATGAATCAATGCCACGGTGACTCTCTCTCTAAATTCCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate