Basic Information
VIS ID
TVIS10014494
Fusion event
HBV-LOC105370834 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1371
Orient
+
Integrated sequence
ACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGT| |TTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGG
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
58042378/57750180 (Hg38)
End
58042378/57750180 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC105370834
Nearest miRNA
hsa-mir-10393/Upstream/2377146; hsa-mir-11181/Downstream/1421003;
Nearest TSS
ENST00000557528/Upstream/4073; ENST00000559684/Downstream/205089;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/42993, chr15-CpG: 148/Downstream/314931
Nearby gene
GCOM1(-32623) ; ALDH1A2(+203244) ;
Upstream sequence
GAAAAAATAACTACTTAATGAGCCCTCTGTCTACCCTTTTGGAACCCAGCTTTCTAAAAGAAGACAAAACTTACCAAACCAACTTATAGAGAAAAGTACT
Downstream sequence
CTCACCCCTAGCTCATTTTCATTCCCTGGCTGACCTACCAGCAGAACCTCCGCCCCCCTGCGGCCCGATACCATCATTTTTAATGAAGTTAatttttatt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate