Basic Information
VIS ID
TVIS10014495
Fusion event
HBV-LOC107984802 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|
Start
1742
Orient
+
Integrated sequence
CCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGT| |TGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATC
Host Sequence
Chromosome
chr15
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
60101560/59809361 (Hg38)
End
60101560/59809361 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA15A
Target gene
LOC107984802
Nearest miRNA
hsa-mir-10393/Upstream/638099; hsa-mir-11181/Downstream/2495297;
Nearest TSS
ENST00000557528/Upstream/119827; ENST00000396057/Downstream/194861;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/119765, chr15-CpG: 17/Downstream/185882
Nearby gene
BNIP2(-119918) ; FOXB1(+194861) ;
Upstream sequence
ctcactcataggtgggaattgaacaatgagaacacatggacacaggaaggggaacatcacacactggggcctgttgtggggtggggggagggggaggagt
Downstream sequence
agcattaggagatatacgtaatgttaaatgacgagttaatgggtgcagcacaccaagatggcacatatatacatatgtaacaaacctgcatgttgtgcac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate