Basic Information
VIS ID
TVIS10014496
Fusion event
HBV-MIR548H4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
308
Orient
+
Integrated sequence
GGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCA| |AAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTC
Host Sequence
Chromosome
chr15
Cytoband
q23
Reference genome
GRCh37/hg19
Start
69410999/69118660 (Hg38)
End
69410999/69118660 (Hg38)
Orient
-
Location type
ncRNA_intronic
Target gene
MIR548H4
Nearest miRNA
hsa-mir-10393/Upstream/316735; hsa-mir-11181/Downstream/960712;
Nearest TSS
ENST00000557528/Upstream/37781; ENST00000559798/Downstream/41924;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/44204, chr15-CpG: 123/Downstream/41452
Upstream sequence
GATTGGCATATGGTAGAAGGGAAGGTACCAGAGGTGGGGATTCATGTATCATAAAGGCATGGACCAGGAAAGAAAGGGGCTAGAAGTGGATGAGATGTCA
Downstream sequence
AGACACAGAAAGGGGAGGAGAAATGAGAATAAGGAGCTCCCCTAGACTCAACTCATCTGGTTTCTTCCATTTTGCAGGGGGTGGTCCTAAGACCAGGGTC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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