Basic Information
VIS ID
TVIS10014498
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
755
Orient
+
Integrated sequence
CAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTA| |TTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGA
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
End
79659226/79625329 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
Nearest miRNA
hsa-mir-1225/Upstream/2756310; hsa-mir-11401/Downstream/1759689;
Nearby gene
MAF(-24604) ; DYNLRB2(+915628) ;
Nearest cancer related gene
MAF(OG, -24604) ;
Upstream sequence
GTGGGGAAGGAATCACAGGGTttattattattattattattattattTTTTAATGTCTAAACTCATTTTGTCTTTGCAACATCAAAACACTGTTGGCAAT
Downstream sequence
TTCCTTTACAACTCATGGCTAATTTACAGAAGGGATTTTTATGAAAATGTTTTCCTTCATTCCCATGGATGGTGATGCTACCTGGGGGGCAGGTACTCAG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate