Basic Information
VIS ID
TVIS10014499
Fusion event
HBV-chr16 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2375
Orient
-
Integrated sequence
GGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAG| |AAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGT
Host Sequence
Chromosome
chr16
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
80000435/79966538 (Hg38)
End
80000435/79966538 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA16D
Nearest miRNA
hsa-mir-1225/Upstream/3097519; hsa-mir-11401/Downstream/1418480;
Nearest TSS
ENST00000527434/Upstream/139388; ENST00000565531/Downstream/74124;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/364898, chr16-CpG: 42/Downstream/574306
Nearby gene
MAF(-365813) ; DYNLRB2(+574419) ;
Nearest cancer related gene
MAF(OG, -365813) ;
Upstream sequence
GGTGCATCCTTTGGCCAGGACGAAAGCTGTTTCCAGTCACCATTTTCTCACAGGGAATGAGTACCTTCCCACATGGCCTTCCTCAACCTTCCTTTCCTTT
Downstream sequence
CTCACCATGGCTGCCAAGAGGGGTTTTGAGCAGCCTCCACCCATCCCAAAGCAGGGAGCATGTTCAGCAAGGAGCCCCGGAGCCCAGCCAGGTCAGCAGC
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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