Basic Information
VIS ID
TVIS10014504
Fusion event
HBV-LOC105371874 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|
Start
1840
Orient
-
Integrated sequence
GTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAA| |TCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGT
Host Sequence
Chromosome
chr17
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
66830723/68834582 (Hg38)
End
66830723/68834582 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105371874
Nearest miRNA
hsa-mir-10226/Upstream/410034; hsa-mir-1250/Downstream/264960;
Nearest TSS
ENST00000595228/Upstream/36760; ENST00000630625/Downstream/43064;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/233145, chr17-CpG: 116/Downstream/491986
Nearby gene
FAM20A(-233628) ; ABCA8(+32708) ;
Upstream sequence
TTTTGAGTGTAAAGGATTTAATTATTATTACTGTTTTTTGTGTGGGTCAATTTTGGCATTTCGGATAATTTTTCTAGAGGTATATTTATCTAATTTAtcc
Downstream sequence
ttccttccttccttccttcctccctccctccctccatctctctctctctctctttctttctttcctttctagaggtatatttatctaatttccttccttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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