Basic Information
VIS ID
TVIS10014510
Fusion event
HBV-chr18 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
390
Orient
+
Integrated sequence
TACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGG| |CGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAG
Host Sequence
Chromosome
chr18
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
41869982/44290017 (Hg38)
End
41869982/44290017 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/4613238; hsa-mir-122/Downstream/680065;
Nearest TSS
ENST00000575820/Upstream/1012367; ENST00000591940/Downstream/241638;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/4448152, chr18-CpG: 180/Downstream/389001
Nearby gene
SYT4(-1012367) ; SETBP1(+390156) ;
Nearest cancer related gene
SETBP1(OG, +390156) ;
Upstream sequence
ATTCTCAAATCTCAGAAGGAAATGGACACACCCACTGCATATCACTCTATTCTGTGCCAGTAACAGGGGCTCTGGCATTCTTTGGCATCTTTCAATCTAC
Downstream sequence
TTTATCACTCTGTAGCACATAGAACCTTGCATTCTGTTCAGTCTAGGTCTGTTTTATACCTCTTGTGACCATAAATTTGTACTAATCATTCTTCTACCTA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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