Basic Information
VIS ID
TVIS10014517
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2338
Orient
+
Integrated sequence
GAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGA| |CTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCG
Host Sequence
Chromosome
chr2
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
163781200/162924690 (Hg38)
End
163781200/162924690 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-128-1/Upstream/2516808; hsa-mir-10b/Downstream/5658253;
Nearest TSS
ENST00000437798/Upstream/85960; ENST00000628960/Downstream/811294;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/580175, chr2-CpG: 28/Downstream/423540
Nearby gene
KCNH7(-85943) ; FIGN(+682918) ;
Upstream sequence
AACCCACTCCCACACCAAACTCAAATTCCTCAGTGAGCTCATCTCAGTGAGGCTTCAGGAAGtaaaacagtactccacacagtgctcgacaagtgtttgt
Downstream sequence
tgaatccagtgaatgaatGGCTCCAGACTGAATTAAATCACATTAAAATATAAAGTGCTGGTAACATTGCagaggcaatgtggaatagcaaaagaagcag
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate