Basic Information
VIS ID
TVIS10014518
Fusion event
HBV-SCN1A-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
561
Orient
+
Integrated sequence
TATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCC| |TCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCC
Host Sequence
Chromosome
chr2
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
167010533/166154023 (Hg38)
End
167010533/166154023 (Hg38)
Orient
+
Location type
Intronic
Target gene
SCN1A-AS1
Nearest miRNA
hsa-mir-128-1/Upstream/5746141; hsa-mir-10b/Downstream/2428920;
Nearest TSS
ENST00000437798/Upstream/4809; ENST00000409043/Downstream/51216;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/199707, chr2-CpG: 31/Downstream/221855
Nearby gene
SCN1A(-4891) ; SCN9A(+41164) ;
Upstream sequence
caaaaaaagtcaggcatagtggtgcatgcctctggtcccagttacttgggaggctaaggtgggtgaattatttgtgcccaggagttcaaggatgcagtga
Downstream sequence
gccatgatcacgccactgctctccagcctaggtgacaacagagcaagaccctctctcTCAGTAAAAAATAAATTTAAAAAAGTTCTCATAAATCCTTAGT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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