VISDB Viral Integration Site DataBase

VIS ID

TVIS10014521

Fusion event

HBV-COL4A4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

S protein|Polymerase|large S protein|middle S protein|

Start

591

Orient

+

Integrated sequence

ATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGA| |AATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCAT

Chromosome

chr2

Cytoband

q36.3

Reference genome

Start

End

227955830/227091114 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-26b-5p ; hsa-mir-150-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-1257 ; hsa-mir-302d-5p ; hsa-mir-302b-5p ; hsa-mir-4778-3p ; hsa-mir-4302 ; hsa-mir-4753-3p ; hsa-mir-6873-3p ; hsa-mir-130b-5p ; hsa-mir-6817-3p ; hsa-mir-7110-3p ; hsa-mir-216b-5p ; hsa-mir-548c-3p

Nearest miRNA

hsa-mir-10b/Upstream/432321; hsa-mir-1244-1/Downstream/381018;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/254715, chr2-CpG: 53/Downstream/72849

Upstream sequence

atttgtctaaaAAAACAGACCAAAAGATCCCCTTCCTGAAATTGGCAGCAGGGAAAGAAAATAGACCCCCTACTATCCCCGCCAAAAAAACCTAGAAGAA

Downstream sequence

ACACGCATCACAGCAAGCTATTTTAATTTATTTTACAATTAAAAcagaagatgagggagagtattgcatccctgaaacatgaacagcctgctacaaaagg