VISDB Viral Integration Site DataBase

VIS ID

TVIS10014524

Fusion event

HBV-LCLAT1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

Polymerase|large S protein|middle S protein|

Start

134

Orient

+

Integrated sequence

CCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAG| |GATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTC

Chromosome

chr2

Cytoband

p23.1

Reference genome

Start

End

30809762/30586896 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-181a-5p ; hsa-mir-30a-5p ; hsa-mir-302b-5p ; hsa-mir-302d-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-181d-5p ; hsa-mir-4262 ; hsa-mir-3919 ; hsa-mir-3942-5p ; hsa-mir-4703-5p ; hsa-mir-4756-3p ; hsa-mir-4766-3p ; hsa-mir-892c-5p ; hsa-mir-30c-5p ; hsa-mir-30d-5p ; hsa-mir-30b-5p ; hsa-mir-30e-5p ; hsa-mir-340-5p ; hsa-mir-568 ; hsa-mir-4495 ; hsa-mir-5680 ; hsa-mir-6835-3p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-130a-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-1468-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-548f-5p ; hsa-mir-548g-5p ; hsa-mir-548x-5p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-548aj-5p ; hsa-mir-548aw ; hsa-mir-188-3p ; hsa-mir-21-3p ; hsa-mir-3591-3p ; hsa-mir-6833-5p ; hsa-mir-1200 ; hsa-mir-378a-5p ; hsa-mir-3911 ; hsa-mir-3190-3p ; hsa-mir-654-5p ; hsa-mir-6721-5p ; hsa-mir-541-3p ; hsa-mir-6878-5p ; hsa-mir-4736 ; hsa-mir-3202 ; hsa-mir-4533 ; hsa-mir-3665 ; hsa-mir-6089 ; hsa-mir-5008-5p ; hsa-mir-7515 ; hsa-mir-4649-3p ; hsa-mir-544b ; hsa-mir-4324 ; hsa-mir-3934-5p ; hsa-mir-6760-5p ; hsa-mir-3908 ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-302b-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-520d-3p ; hsa-mir-372-3p ; hsa-mir-520e ; hsa-mir-302e ; hsa-mir-520c-3p ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302a-3p ; hsa-mir-3149 ; hsa-mir-203a-3p ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-302c-5p ; hsa-mir-4446-5p

Nearest miRNA

hsa-mir-1301/Upstream/2590447; hsa-mir-10b/Downstream/1945257;

Nearest TSS

Nearest CpG islands

None/Target, chr2-CpG: 135/Upstream/139042, chr2-CpG: 146/Downstream/550559

Upstream sequence

TTTAATATTGTTCAAATGTCTTTAGTCTTTAAAAAGGAAAAAAAGACTTAAAAAAAACCATGCAACTACACGGACACTTTTTATAACcccctcaccatgc

Downstream sequence

acccctactccaagcttctacactacatctttctttgcttcagatataaacttcttggaagagctgttgatgaactgtcatcacacccttattccctaat