Basic Information
VIS ID
TVIS10014529
Fusion event
HBV-LOC105373053 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
1369
Orient
+
Integrated sequence
ATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATC| |GTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGG
Host Sequence
Chromosome
chr22
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
43773206/43377200 (Hg38)
End
43773206/43377200 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA22A
Target gene
LOC105373053
Nearest miRNA
hsa-mir-1281/Upstream/1453903; hsa-let-7a-3/Downstream/1823754;
Nearest TSS
ENST00000624155/Upstream/33812; ENST00000450750/Downstream/23131;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/32921, chr22-CpG: 112/Downstream/34194
Nearby gene
SCUBE1(-33812) ; MPPED1(+34814) ;
Upstream sequence
GCTGAGCTGCAATGCTTTGTGGTTCTTCTGATGCCTTCAGAAGGGGTATGTGAGACCACACGTTCAGGGGCTGGGGGGCTGCCTCCCGTTATAACTCATG
Downstream sequence
AGAGTTCCTTTCTGACCCTCATTTTAAGTTCGTTTTACATCACGAGTGTTTTAAGGTTTTTGGTGTGTGttttttttttttttttttttttttttttttG
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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